Equine Herpesvirus 1 Utilizes a Novel Herpesvirus Entry Receptor
نویسندگان
چکیده
منابع مشابه
Equine herpesvirus 1 utilizes a novel herpesvirus entry receptor.
The well-described herpesvirus entry receptors HveA (TNFRSF14), HveB (nectin 2), and HveC (nectin 1) have been shown to mediate the entry of alphaherpesviruses. Our findings showed that the alphaherpesvirus equine herpesvirus 1 (EHV-1) efficiently entered and replicated in CHO-K1 cells that lack the entry receptors HveA, HveB, and HveC, demonstrating that EHV-1 utilizes a unique entry receptor....
متن کاملEquine herpesvirus-1 consensus statement.
Equine herpesvirus-1 is a highly prevalent and frequently pathogenic infection of equids. The most serious clinical consequences of infection are abortion and equine herpesvirus myeloencephalopathy (EHM). In recent years, there has been an apparent increase in the incidence of EHM in North America, with serious consequences for horses and the horse industry. This consensus statement draws toget...
متن کاملA critical view on Equine Herpesvirus-1 and on Equine Herpesvirus-associated Myeloencephalopathy (EHM)
An infection with Equine herpesvirus type 1 (EHV-1), officially and by convention now called EQUID Herpesvirus, is the cause for Equine herpesvirus-associated Myeloencephalopathy or EHM. In 2008 the USDA declared this syndrome an ‘emerging disease’ among horse populations in the U.S.A., which indicates that EHM is perceived as an expanding problem that is observed more frequently when compared ...
متن کاملEquus caballus major histocompatibility complex class I is an entry receptor for equine herpesvirus type 1.
In this study, Equus caballus major histocompatibility complex class I (MHC-I) was identified as a cellular entry receptor for the alphaherpesvirus equine herpesvirus type 1 (EHV-1). This novel EHV-1 receptor was discovered using a cDNA library from equine macrophages. cDNAs from this EHV-1-susceptible cell type were inserted into EHV-1-resistant B78H1 murine melanoma cells, these cells were in...
متن کاملNovel entry pathway of bovine herpesvirus 1 and 5.
Herpesviruses enter cells by a yet poorly understood mechanism. We visualized the crucial steps of the entry pathway of bovine herpesvirus 1 (BHV-1) and BHV-5 by transmission and scanning electron microscopy, employing cryotechniques that include time monitoring, ultrarapid freezing, and freeze substitution of cultured cells inoculated with virus. A key step in the entry pathway of both BHV-1 a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Virology
سال: 2005
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.79.5.3169-3173.2005